US Patent Issued to Hoffmann-La Roche on April 22 for "Combination therapy with targeted 4-1BB (CD137) agonists" (Swiss Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,153, issued on April 22, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Combination therapy with targeted 4-1BB (CD137) agonists" was invented by Christina Claus (Ennetbaden, Switzerland), Claudia Ferrara Koller (Zug, Switzerland), Christian Klein (Bonstetten, Switzerland), Johannes Sam (Baden, Switzerland) and Pablo Umana (Wollerau, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to combination therapies employing 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, in combination with HER-2 targeting agents, the use of these combination therapies for the tr...