ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,386, issued on Oct. 21, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.) and Genentech Inc. (South San Francisco, Calif.).

"Processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyrido[3,4-bindoles" was invented by Haiming Zhang (San Mateo, Calif.), Jie Xu (San Mateo, Calif.), Georg Wuitschik (Basel, Switzerland), Remy Angelaud (San Francisco), Sebastian Herold (Bad Saeckingen, Germany), Alfred Stutz (Zurich), Tobias Bruetsch (Dietikon, Switzerland) and Johannes Burkhard (San Mateo, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyri...