US Patent Issued to H. Lee Moffitt Cancer Center and Research Intitute. on Dec. 9 for "CD83-binding chimeric antigen receptors" (Minnesota, Florida Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,254, issued on Dec. 9, was assigned to H. Lee Moffitt Cancer Center and Research Intitute. Inc. (Tampa, Fla.).

"CD83-binding chimeric antigen receptors" was invented by Marco Davila (Tampa, Fla.) and Brian Betts (Minneapolis).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compositions and methods for preventing graft versus host disease (GVHD) in subjects receiving donor cells. In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer suppress alloreactive donor cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to...