ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,749, issued on March 18, was assigned to Guardant Health Inc. (Palo Alto, Calif.).

"Systems and methods to detect rare mutations and copy number variation" was invented by AmirAli Talasaz (Atherton, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of b...