US Patent Issued to Guardant Health on April 29 for "Computational modeling of loss of function based on allelic frequency" (California Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,288,598, issued on April 29, was assigned to Guardant Health Inc. (Palo Alto, Calif.).

"Computational modeling of loss of function based on allelic frequency" was invented by Catalin Barbacioru (Fremont, Calif.), Marcin Sikora (Redwood City, Calif.) and Darya Chudova (San Jose, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure relates to computer technology for precision diagnosis of various states of genetic material such as a gene sequenced from cell-free DNA in a sample. The state may include a somatic homozygous deletion, a somatic heterozygous deletion, a copy number variation, or other states. A computer system may generate compe...