ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,354, issued on April 22, was assigned to Guardant Health Inc. (Palo Alto, Calif.).

"Systems and methods to detect rare mutations and copy number variation" was invented by AmirAli Talasaz (Atherton, Calif.) and Stefanie Ann Ward Mortimer (Morgan Hill, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a method for monitoring residual disease in a subject. Generally, the method comprises determining a frequency of cancer mutations from a first sample obtained from a tumor biopsy from the subject; determining a frequency of the cancer mutations discovered in the first sample from a second sample comprising cell-free d...