ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,605, issued on July 1, was assigned to Gruenenthal GmbH (Aachen, Germany).

"Substituted pyrrolidine amides II" was invented by Florian Jakob (Aachen, Germany), Jo Alen (Averbode, Belgium), Sebastian Krueger (Aachen, Germany), Markus Schade (Aachen, Germany), Daniela Friebe (Duesseldorf, Germany) and Stephanie Hennen (Aachen, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to compounds according to general formula (I),which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor."

The patent was f...