US Patent Issued to GRAIL on Dec. 30 for "Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing" (California Inventors)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,726, issued on Dec. 30, was assigned to GRAIL Inc. (Menlo Park, Calif.).

"Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing" was invented by Anton Valouev (Palo Alto, Calif.) and Arash Jamshidi (Redwood City, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are methods of preparing dual-indexed nucleic acid libraries for methylation profiling using bisulfite conversion sequencing. In various embodiments, the methods use a two-step indexing process to tag bisulfite-treated DNA with unique molecular identifiers (UMIs)."

The patent was filed on Feb. 20, 2025, under Application No. 19/058,911.

*F...