US Patent Issued to GRAIL on April 1 for "Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing" (California Inventors)

ALEXANDRIA, Va., April 2 -- United States Patent no. 12,264,364, issued on April 1, was assigned to GRAIL Inc. (Menlo Park, Calif.).

"Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing" was invented by Anton Valouev (Palo Alto, Calif.) and Arash Jamshidi (Redwood City, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are methods of preparing dual-indexed nucleic acid libraries for methylation profiling using bisulfite conversion sequencing. In various embodiments, the methods use a two-step indexing process to tag bisulfite-treated DNA with unique molecular identifiers (UMIs)."

The patent was filed on Dec. 20, 2022, under Application No. 18/084,955.

*F...