ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,443, issued on Jan. 13, was assigned to GlaxoSmithKline Biologicals SA (Rixensart, Belgium).
"Conjugate production" was invented by Ralph Leon Biemans (Rixensart, Belgium) and Elisabeth Marie Monique Bertaud (Isnes, Belgium).
According to the abstract* released by the U.S. Patent & Trademark Office: "This application relates to methods for the production of polysaccharide antigen-carrier protein conjugates, in particular conjugates of Group B Streptococcus (GBS) capsular polysaccharide and a carrier protein, in particular CRM197. The methods comprise a hydroxyapatite chromatography step in order to separate the conjugate from free polysaccharide and free carrier protein."
The pa...