US Patent Issued to GENZYME on July 22 for "Anti-alpha beta TCR binding polypeptides with reduced fragmentation" (New Jersey Inventor)

ALEXANDRIA, Va., July 23 -- United States Patent no. 12,365,734, issued on July 22, was assigned to GENZYME Corp. (Cambridge, Mass.).

"Anti-alpha beta TCR binding polypeptides with reduced fragmentation" was invented by Huawei Qiu (Bridgewater, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is related to improved compositions and methods for treating T-cell-mediated diseases and disorders (e.g., autoimmune disorders, graft-versus-host-disease, and graft rejection). Provided are anti-apBetaTCR binding polypeptides, including antibodies, which comprise at least one amino acid substitution or modification that increases the stability of the binding polypeptide by reducing fragmentati...