ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 12,213,979, issued on Feb. 4, was assigned to Genzyme Corp. (Cambridge, Mass.).
"Biomarkers of methotrexate-induced immune tolerance" was invented by Alexandra Joseph (Lexington, Mass.), Johnson Tran (Sacramento, Calif.) and Susan M. Richards (Sudbury, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides methods of treating a disease, such as Pompe disease, in a subject, comprising detecting an erythropoiesis biomarker in a sample of the subject after administration of methotrexate and a therapeutic agent to the subject, and administering further treatment with or without concurrently administering additional immune toleranc...