US Patent Issued to GENZYME on Dec. 23 for "Fc containing polypeptides with altered glycosylation and reduced effector function" (Massachusetts Inventors)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,503,498, issued on Dec. 23, was assigned to GENZYME Corp. (Cambridge, Mass.).

"Fc containing polypeptides with altered glycosylation and reduced effector function" was invented by Clark Pan (Sutton, Mass.) and Huawei Qiu (Westborough, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine or threonine residue at amino acid position 300, accordi...