ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,228, issued on Dec. 9, was assigned to GENOFOCUS Co. LTD. (Daejeon, South Korea) and EUBIOLOGICS.Co. LTD. (Seoul, South Korea).

"CRM197 protein expression method" was invented by Jeong Hyun Kim (Gyeonggi-do, South Korea), Hyun-Do Kim (Gwangju, South Korea), Eun-Hye Park (Daejeon, South Korea), Jung Hyun Kang (Daejeon, South Korea), Jae Gu Pan (Sejong, South Korea), Eui Joong Kim (Daejeon, South Korea), Chankyu Lee (Gangwon-do, South Korea) and Minchul Park (Gyeonggi-do, South Korea).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a signal sequence for expressing a CRM197 protein in Escherichia coli and secreting same in...