ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,459,957, issued on Nov. 4, was assigned to GENENTECH INC. (South San Francisco, Calif.).

"Therapeutic compounds and methods" was invented by Samantha Alyson Green (South San Francisco, Calif.), Jessica Marie Grandner (South San Francisco, Calif.), Steven Thomas Staben (South San Francisco, Calif.), Neri Amara (South San Francisco, Calif.), Vishva M. Dixit (South San Francisco, Calif.) and Elisia Villemure (South San Francisco, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a compound of formula (I):or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the s...