US Patent Issued to Genentech on May 6 for "Methods of producing two chain proteins in prokaryotic host cells" (California Inventors)

ALEXANDRIA, Va., June 10 -- United States Patent no. 12,291,712, issued on May 6, was assigned to Genentech Inc. (South San Francisco, Calif.).

"Methods of producing two chain proteins in prokaryotic host cells" was invented by Karthik Veeravalli (San Francisco) and Rebekah McKenna (Hayward, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and host cells for producing a polypeptide containing two chains, such as an antibody, half-antibody, antibody fragment, or one-armed antibody. The methods and host cells allow for two-chain polypeptide production using expression of polynucleotides encoding the polypeptide chains from extra-chromosomal polynucleotide(s), and expression of ...