ALEXANDRIA, Va., July 9 -- United States Patent no. 12,351,858, issued on July 8, was assigned to GEN-PROBE Inc. (San Diego).
"Multiphase nucleic acid amplification" was invented by Norman C. Nelson (San Diego), Lyle J. Arnold Jr. (Poway, Calif.), Lizhong Dai (San Diego), Steven Phelps (La Jolla, Calif.) and Jijumon Chelliserry (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Improved methods for use in nucleic acid amplification, including multiplex amplification, where the amplification is carried out in two or more distinct phases are disclosed. The first phase amplification reaction preferably lacks one or more components required for exponential amplification. The lacking component is subsequen...