ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,313, issued on Dec. 2, was assigned to GammaDelta Therapeutics Ltd (London).
"Gene armoring" was invented by Istvan Kovacs (London), Andre Goncalo do Espirito Santo Simoes (London), Sam Illingworth (London), Jyothi Kumaran (London), Oliver Nussbaumer (London) and Rajeev Karattil (London).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides compositions and methods for engineering GammaDelta T cells (e.g., vDelta1 T cells and vDelta2 T cells) with an IL-15 receptor Beta subunit (IL-15RBeta), e.g., by transduction with a viral vector, to restore IL-15 responsiveness. Further provided are populations of engineered GammaDelta T c...