ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,858, issued on July 1, was assigned to FULL CIRCLES THERAPEUTICS INC. (Cambridge, Mass.).

"Targeted genome modification using circular single-stranded DNA" was invented by Jin Hang Huh (Watertown, Mass.) and Qun Shan (Belmont, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to methods for generating one or more genetically modified cells by using a circular single stranded DNA (CiSSD) as a donor template and targeting genome modification. These methods include transferring one or more DNA polynucleotides into the cell for site-specific nuclease-mediated DNA repair and selecting one or more cells having the trans...