ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,348, issued on April 22, was assigned to Fudan University (Shanghai).

"Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate" was invented by Fener Chen (Shanghai), Dang Cheng (Shanghai), Zedu Huang (Shanghai), Minjie Liu (Shanghai), Huashan Huang (Shanghai), Meifen Jiang (Shanghai) and Lulu Wang (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenat...