ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,402, issued on Aug. 26, was assigned to Fred Hutchinson Cancer Center (Seattle).

"Reducing CD33 expression to selectively protect therapeutic cells" was invented by Hans-Peter Kiem (Seattle), Olivier Humbert (Seattle) and Roland B. Walter (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells and targeting non-therapeutic cells with an anti-CD33 therapy. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a ...