ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,456,541, issued on Oct. 28, was assigned to Foundation Medicine Inc. (Boston).
"Analysis of genetic variants" was invented by James Xin Sun (Newton, Mass.) and Roman Yelensky (Newton, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Methods and systems for analyzing genetic variants are disclosed. The methods and systems can be used to classify a variant in a tumor sample as germline, somatic, subclonal, or ambiguous. The variant can be classified by fitting a genome-wide copy number model to a sequence coverage input and a SNP allele frequency input. The fitted model can be used to determine a tumor purity, and a total copy number and a minor allel...