ALEXANDRIA, Va., June 9 -- United States Patent no. 12,285,495, issued on April 29, was assigned to FONDAZIONE TELETHON ETS (Rome).
"Genome editing methods and constructs" was invented by Alberto Auricchio (Pozzuoli, Italy) and Manel Llado Santaeularia (Pozzuoli, Italy).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method of integrating an exogenous DNA sequence into a genome of a cell comprising contacting the cell with: a) a donor nucleic acid comprising: -at least one STOP codon and a translation initiation sequence (TIS) or-a ribosomal skipping sequence, and-said exogenous DNA sequence wherein said donor nucleic acid is flanked at 5' and 3' by inverted targeting sequenc...