ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,233, issued on July 15, was assigned to Fermelanta Inc. (Ishikawa, Japan).
"Production method of (R)-reticuline" was invented by Akira Nakagawa (Nonoichi, Japan) and Hiromichi Minami (Nonoichi, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a production method of (R)-reticuline including: a step for obtaining a recombinant host cell by inserting, into a host cell, a gene 1 which is composed of a nucleotide sequence having at least 70% homology to a nucleotide sequence of SEQ ID NO: 2 and which is DNA encoding a protein having an enzymatic activity of CYP80Y2, and a gene 2 which is composed of a nucleotide seque...