US Patent Issued to Farmabios on March 11 for "Process for the preparation of cortexolone 17Alpha-propionate and new hydrated crystalline form thereof" (Italian Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,247,048, issued on March 11, was assigned to Farmabios S.P.A. (Italy).

"Process for the preparation of cortexolone 17Alpha-propionate and new hydrated crystalline form thereof" was invented by Ponzinibi Matteo (Lodi, Italy), Roberto Arosio (Civate, Italy), Brusasca Marco (Valenza, Italy) and Di Giacomo Mario (Cenate Sotto, Italy).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to a process for the preparation of cortexolone 17Alpha-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III) in which R is a hydrogen atom or a methyl group, in the presence of a dilute solution of acetic acid.The present...