ALEXANDRIA, Va., June 4 -- United States Patent no. 12,319,727, issued on June 3, was assigned to EXORPHIA INC. (Tokyo).
"Exosome-targeted DNA vaccine" was invented by Ken Ishii (Tokyo), Kouji Kobiyama (Ibaraki, Japan) and Tomohiro Kanuma (Ibaraki, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "In order to further increase antigenicity to provide a DNA vaccine which is clinically usable in humans, the inventors of the present invention focused on exosomes, which are garnering attention as tools for DDS, and discovered that an exosome expressing a fusion antigen of an exosome (extracellular microparticle)-constituent protein and a vaccine antigen has excellent cytotoxic T-cell inducibility. Consequently...