ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,510, issued on May 13, was assigned to Exact Sciences Corp. (Madison, Wis.).
"Methylation assay" was invented by Graham P. Lidgard (Middleton, Wis.), Michael J. Domanico (Middleton, Wis.), Hatim Allawi (Middleton, Wis.) and Hongzhi Zou (Middleton, Wis.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for detecting a methylated genomic locus is provided. In certain embodiments, the method comprises: a) treating a nucleic acid sample that contains both unmethylated and methylated copies of a genomic locus with an agent that modifies cytosine to uracil to produce a treated nucleic acid; b) amplifying a product from the treated nucleic acid using...