ALEXANDRIA, Va., June 16 -- United States Patent no. 12,306,180, issued on May 20, was assigned to ETH Zurich (Zurich).
"Tri-functional crosslinking reagents" was invented by Erick Moran Carreira (Zumikon, Switzerland), Michael Andreas Schafroth (Zurich), Nadine Sobotzki (Zurich) and Bernd Wollscheid (Zurich).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to tri-functional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) a hydrazone group for the capturing of oxidized receptor-glycoproteins and (iii) an affinity group selected from azides and aklynes for the ...