ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,390,478, issued on Aug. 19, was assigned to ESTETRA SRL (Liege, Belgium).

"Compounds and their uses for alleviating menopause-associated symptoms" was invented by Melanie Taziaux (Liege, Belgium), Glwadys Rausin (Trooz, Belgium), Maud Jost (Liege, Belgium) and Marie Mawet (Angleur, Belgium).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at specified daily doses, optionally in combination with a proges...