ALEXANDRIA, Va., June 12 -- United States Patent no. 12,295,976, issued on May 13, was assigned to EPICENTRX INC. (La Jolla, Calif.).
"Personalized cancer vaccines" was invented by Christopher Larson (San Diego), Bryan T. Oronsky (Los Altos Hills, Calif.) and Tony R. Reid (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides for a recombinant adenoviral vector comprising a recombinant oncolytic adenovirus which has: (1) a modified transcription regulatory sequence wherein the adenoviral vector is transcriptionally active in cancer cells and/or hyperproliferative cells and transcriptionally attenuated in normal cells, and (2) a transgene encoding one or more cancer antigens that are...