ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,563, issued on March 25, was assigned to EMPIRICO INC. (San Diego).
"Modified oligonucleotides" was invented by Darren H. Wakefield (Fitchburg, Wis.), Lauren Almeida (Madison, Wis.), David Rozema (Cross Plains, Wis.), Omri Gottesman (San Diego) and David Lewis (Madison, Wis.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are compositions comprising modified oligonucleotides. In some embodiments, the oligonucleotide includes a hydrophobic moiety. In some embodiments, the oligonucleotide includes a vinyl phosphonate. In some embodiments, the oligonucleotide includes modified oligonucleotide sugars such as 2' modified ribose molecules...