US Patent Issued to Element Biosciences on July 15 for "Single-stranded splint strands and methods of use" (California Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,193, issued on July 15, was assigned to Element Biosciences Inc. (San Diego).

"Single-stranded splint strands and methods of use" was invented by William Light (Poway, Calif.), Ryan Kelley (San Diego) and Junhua Zhao (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides compositions comprising nucleic acid single-stranded splint strands, including kits, and methods that employ the single-stranded splint strands. The single-stranded splint strands can hybridize to portions of linear library molecules to form circularized library-splint complexes having a nick, where the nick can be ligated to form covalently closed...