ALEXANDRIA, Va., April 9 -- United States Patent no. 12,270,056, issued on April 8, was assigned to ELEMENT BIOSCIENCES INC. (San Diego).
"Engineered polymerases" was invented by Mark Ambroso (Escondido, Calif.), Tyler Lopez (Winchester, Calif.), Michael Klein (Encinitas, Calif.), Virginia Saade (San Diego) and Matthew Kellinger (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are engineered variants of archaeal, prokaryotic, and eukaryotic polymerases that exhibit enhanced thermostability, enhanced incorporation of 3' modified nucleotides, and improved uracil-tolerance, in polymerase-catalyzed nucleotide extension reactions relative to wild type polymerase enzymes. Also provided are...