ALEXANDRIA, Va., June 16 -- United States Patent no. 12,303,505, issued on May 20, was assigned to Eisai R&D Management Co. Ltd. (Tokyo).
"Tumor-treating pharmaceutical composition" was invented by Yoichi Ozawa (Tsukuba, Japan), Yusaku Hori (Tokyo), Kazuhiko Yamada (Tsukuba, Japan), Hiroshi Kamiyama (Tsukuba, Japan) and Masahiro Matsuki (Tsukuba, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a pharmaceutical composition for treating a tumor, which is used in combination therapy of lenvatinib and (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carbo...