ALEXANDRIA, Va., June 16 -- United States Patent no. 12,303,499, issued on May 20, was assigned to Eisai R&D Management Co. Ltd. (Tokyo).

"Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds" was invented by Geoffrey S. Hird (Chapel Hill, N.C.), Ganesh S. P. Bommareddy (Durham, N.C.), Anjali Joshi (Cary, N.C.) and James McShane (Raleigh, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "An aqueous pharmaceutical formulation of a solubilizing agent with a pyridone compound that is useful as an inhibitor to non-NMDA receptors, particularly to the AMPA receptor is disclosed herein. In some embodiments the pyridone compound is supersaturated in aqueous solution at pH between 6 and 8. The...