ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,544,221, issued on Feb. 10, was assigned to Edwards Lifesciences Corp. (Irvine, Calif.).

"Methods of conditioning sheet bioprosthetic tissue" was invented by Jeffrey S. Dove (Gualala, Calif.), Bin Tian (Irvine, Calif.), Ralph Schneider (Trabuco Canyon, Calif.), Jeffrey S. Cohen (Irvine, Calif.), Ivan Jankovic (Roseville, Minn.), John F. Migliazza (Belmont Shores, Calif.), Gregory A. Wright (Orange, Calif.), James M. Young (Ladera Ranch, Calif.) and Louis A. Campbell (Santa Ana, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous s...