ALEXANDRIA, Va., June 10 -- United States Patent no. 12,290,549, issued on May 6, was assigned to Duke University (Durham, N.C.).

"Method of reducing titers of antibodies specific for a therapeutic agent" was invented by Priya S. Kishnani (Durham, N.C.), Suhrad G. Banugaria (Durham, N.C.), Dwight D. Koeberl (Durham, N.C.) and Sean N. Prater (Durham, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities,...