ALEXANDRIA, Va., June 4 -- United States Patent no. 12,318,616, issued on June 3, was assigned to Duke University (Durham, N.C.).

"Systems and methods for determining optimal temporal patterns of neural stimulation" was invented by Warren M. Grill (Durham, N.C.), Isaac Cassar (Durham, N.C.) and Nathan Titus (Durham, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Systems and methods for determining optimal temporal patterns of neural stimulation are disclosed. According to an aspect, a method includes selecting a temporal pattern for neural stimulation. The method also includes determining a mutation type for altering a pattern of pulses of the temporal pattern. The method also includes identifying a loc...