US Patent Issued to DEFENCE THERAPEUTICS on July 8 for "Conjugates enhancing total cellular accumulation" (Canadian Inventor)

ALEXANDRIA, Va., July 9 -- United States Patent no. 12,350,346, issued on July 8, was assigned to DEFENCE THERAPEUTICS INC. (Sherbrooke, Canada).

"Conjugates enhancing total cellular accumulation" was invented by Simon Beaudoin (Sherbrooke, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide produ...