ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,441,685, issued on Oct. 14, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).
"Compounds and methods for treating cancer" was invented by James Bradner (Weston, Mass.), Michael Erb (Boston) and Jun Qi (Sharon, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds ...