US Patent Issued to CRYSTAL BIOSCIENCE on Sept. 9 for "Transgenic animal for producing diversified antibodies that have the same light chain I" (California Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,408,640, issued on Sept. 9, was assigned to CRYSTAL BIOSCIENCE INC. (Emeryville, Calif.).

"Transgenic animal for producing diversified antibodies that have the same light chain I" was invented by Philip A. Leighton (San Francisco), William Don Harriman (Alameda, Calif.) and Robert Etches (Oakland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides, among other things, strategies for minimizing antibody diversification in a transgenic animal that uses gene conversion for antibody diversification. In some embodiments, the animal may comprise a genome comprising an endogenous immunoglobulin light chain locus comprising: (a) a f...