US Patent Issued to CRYSTAL BIOSCIENCE on Sept. 30 for "Transgenic chicken that makes antibodies with long CDR-H3S stabilized by multiple disulfide bridges and diversified by gene conversion" (California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,428,471, issued on Sept. 30, was assigned to CRYSTAL BIOSCIENCE INC. (Emeryville, Calif.).

"Transgenic chicken that makes antibodies with long CDR-H3S stabilized by multiple disulfide bridges and diversified by gene conversion" was invented by William Don Harriman (Alameda, Calif.) and Philip A. Leighton (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides, among other things, a transgenic chicken. In some embodiments, the transgenic chicken comprises B cells in which the endogenous immunoglobulin heavy chain locus comprises: (a) a functional immunoglobulin heavy chain gene comprising a nucleic acid encoding a heavy ch...