US Patent Issued to CRISPR THERAPEUTICS on July 1 for "Gene-edited natural killer cells" (Massachusetts Inventors)

ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,655, issued on July 1, was assigned to CRISPR THERAPEUTICS AG (Zug, Switzerland).

"Gene-edited natural killer cells" was invented by Valentin Sluch (South Boston, Mass.), Alireza Rezania (South Boston, Mass.), Jason Sagert (South Boston, Mass.) and Danielle Swain (South Boston, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to, inter alia, an engineered cell (e.g., iPSC, IPS-derived NK, or NK cell) comprising a disrupted B2M gene and an inserted polynucleotide encoding one or more of SERPINB9, a fusion of IL15 and IL15RAlpha, and/or HLA-E. The engineered cell can further comprise a disrupted CIITA gene and an inser...