US Patent Issued to Cornell University on Sept. 9 for "I domain chimeric antigen receptor specific to ICAM-1" (New York Inventor)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,235, issued on Sept. 9, was assigned to Cornell University (Ithaca, N.Y.).

"I domain chimeric antigen receptor specific to ICAM-1" was invented by Moonsoo Jin (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to chimeric antigen receptors (CARs) specific to ICAM-1 comprising I domain of the AlphaL subunit of human lymphocyte function-associated antigen 1 (LFA-1). The invention particularly relates to CARs comprising human I domains having different affinities (1 mM to 1 nM Kd) to ICAM-1. CAR T cells comprising human I domain having a low affinity (1 to 200 MuM Kd) to ICAM-1 can avoid targeting healthy tissues wi...