US Patent Issued to Cornell University on Sept. 9 for "Compositions and methods for gene targeting using CRISPR-Cas and transposons" (New York Inventor)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,429, issued on Sept. 9, was assigned to Cornell University (Ithaca, N.Y.).

"Compositions and methods for gene targeting using CRISPR-Cas and transposons" was invented by Joseph E. Peters (Ithaca, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compositions and methods for transposon-CRISPR-based DNA editing. The compositions and methods include a modified TnsA protein that is altered from its original sequence found in Aeromonas salmonicida, and provides improved transposition frequency, and is functional in a heterologous system. The TnsA protein is used in a system with transposon proteins TnsB, TnsC, TniQ, Cas proteins Cas8f, Ca...