ALEXANDRIA, Va., March 26 -- United States Patent no. 12,257,254, issued on March 25, was assigned to Convalife (Shanghai) Co. Ltd. (Shanghai).

"Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent" was invented by Stephen Joseph Shuttleworth (Oxfordshire, Great Britain) and Andrew David Whale (Oxfordshire, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to a pharmaceutical composition comprising a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and at least one second agent selected from the group consisting of signal transduction pathway inhibitors, tumour immunotherapeutics, agents inhib...