US Patent Issued to CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS on July 22 for "Etanercept variants with improved therapeutical effect" (Spanish Inventors)

ALEXANDRIA, Va., July 23 -- United States Patent no. 12,365,720, issued on July 22, was assigned to CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (Madrid).

"Etanercept variants with improved therapeutical effect" was invented by Antonio Alcami Pertejo (Madrid), Sergio Martin Pontejo (Madrid) and Carolina Sanchez Fernandez (Madrid).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides improved Etanercept variants which comprise one (A105E), preferably two (A105E/L106F), amino acid substitutions regarding the Etanercept original amino acid sequence of SEQ ID NO: 3. These variants inhibit TNF activity but fail to neutralize human LTAlpha (hLTAlpha). Thus, they are proposed herein as a g...