US Patent Issued to Conagen on Sept. 16 for "Biosynthetic production of gamma- and delta-lactones using cytochrome P450 enzymes having subterminal hydroxylase activity" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,028, issued on Sept. 16, was assigned to Conagen Inc. (Bedford, Mass.).

"Biosynthetic production of gamma- and delta-lactones using cytochrome P450 enzymes having subterminal hydroxylase activity" was invented by Hui Chen (North Billerica, Mass.) and Xiaodan Oliver Yu (Lexington, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods for making lactones comprising incubating a cellular system expressing a heterologous cytochrome P450 (CYP450) protein with a medium comprising straight chain fatty acids to produce subterminal hydroxy fatty acids, and incubating a yeast cell culture with the subterminal hydroxy fatty acids to...