US Patent Issued to Codexis on Sept. 9 for "Ketoreductase polypeptides for the synthesis of chiral compounds" (California, New Jersey Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,410, issued on Sept. 9, was assigned to Codexis Inc. (Redwood City, Calif.).

"Ketoreductase polypeptides for the synthesis of chiral compounds" was invented by Oscar Alvizo (Fremont, Calif.), Nicholas J. Agard (San Francisco), Xinkai Xie (Castro Valley, Calif.), David Entwistle (San Carlos, Calif.) and Birgit Kosjek (Westfield, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing...