ALEXANDRIA, Va., July 23 -- United States Patent no. 12,365,881, issued on July 22, was assigned to Codexis Inc. (Redwood City, Calif.).
"Ketoreductase polypeptides" was invented by Emily Mundorff (Garden City, N.Y.) and Erik Jan De Vries (Livermore, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the...